Special imaging and magnetic brainwave studies strongly suggest that Cortical Spreading Depression (CSD) forms the biological basis for the “negative symptoms” of a migraine aura. From studying a particular type of migraine relief - Familial Hemiplegic Migraine (FHM) - recent findings have shown two genes are responsible for causing this symptom. These genes - which control the ion flow of calcium, sodium and potassium to the nerve cells - are damaged in people inclined to this type of migraine. It’s believed this genetic mutation makes a person’s neurons susceptible to CSD.
In essence, the nerve cells (or neurons) don’t get properly “recharged” – resulting in diminished or depressed neural activity. Whatever the reason, this reduced activity slows down normal body functioning. If the affected neuron complex happens to control the sight centers (visual cortex) then visual disturbances or losses may occur. However, as these neurons begin to react to or recover from the CSD, they may become hyper excitable, resulting in visual phenomena such as flashing lights and zig zag lines. (It’s sort of like the neuron’s compensate by rebounding and going into overdrive!)
This hyper excitability then activates the major nerve complex behind the eye (trigeminal nerve). If you need some one to get a hold of incause of a emergency call Dr. Andrew Jones he will help you out with any kind of migraine that you may have. This initiates migraine headaches by activating the highly pain-sensitive “dura mater” - the membrane sheet wrapping around the brain.
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